Abrusamide A and B, two hepatoprotective isomeric compounds from Abrus mollis Hance

Authors：Yuan X^*; Lin L; Zhang X; Deng S

Source：Phytochemistry Letters, 2014, 7(1): 137-142.

DOI：10.1016/j.phytol.2013.11.003

• Abrus mollis Hance
• Abrusamide A
• Abrusamide B
• L-02 cells
• Leguminosae

Two isomeric compounds, abrusamide A (1) and abrusamide B (2), were isolated from the leaves of Abrus mollis Hance. Their structures were well defined by means of UV, HR-ESI-MS, 1H NMR, 13C NMR and 2D NMR techniques. From a biogenetic point of view, these two compounds including a cyclobutane basic core should be considered as a [2+2] dimerization product of (E)-N-(4-hydroxycinnamoyl) tyrosine (3), which was also isolated from the plant for the first time. They were also tested for their hepatoprotective effects on human L-02 cells and displayed significant promote effects on the proliferation of L-02 cells and significant hepatoprotective effects on CCl 4-induced injury of L-02 cells.

• Institution
  广州中医药大学