A pilot study on (99)mTc-3PRGD2 scintigraphy in diagnosis of brain glioma

摘要

The (99)mTc-3PRGD(2) targeted SPECT/CT scanning was of significance in detecting differentiated glioma. hi this work, the diagnostic value of (99)mTc-3PRGD(2) scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with (99)mTc-3PRGD(2) at a mean radioactivity of 849+/-115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting alpha v beta 3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation (TIN ratio) and alpha v beta 3 expression level were analyzed. The TIN ratios in brain glioma were proportionally correlated to alpha v beta 3 positive cell percentage (R-2=0.9253, p<0.05). This study primarily evaluated the clinical application of (99)mTc-3PRGD(2) SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

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