miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma

作者：Chen, Kun^*; Wang, Zheng; Zong, Qi-Bei; Zhou, Meng-Ying; Chen, Qing-Fa

来源：American Journal of Cancer Research, 2022, 13(4): 1241-1251.

DOI：10.7150/jca.62652

• miR-497-5p
• RSPO2
• Oncogenesis
• The Wnt/beta-catenin pathway
• GBM

Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/beta-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt/beta-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings.

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