FBXO31 suppresses lipogenesis and tumor progression in glioma by promoting ubiquitination and degradation of CD147

作者：Feng, Yan; Liu, Mingli; Xie, Peng; Dong, Ruifeng; Hao, Zhongfei^*

来源：PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2022, 163: 106667.

DOI：10.1016/j.prostaglins.2022.106667

• FBXO31
• Lipogenesis
• Tumor progression
• Glioma
• CD147

Glioma is the most frequent tumor occurred in brain and spinal cord with a high mortality and morbidity. This study aimed to explore the effects of FBXO31 on lipid synthesis and tumor progression in glioma. The expression of FBXO31 was low in glioma tissues and cell lines, which indicated poor prognosis in glioma patients. Over-expression of FBXO31 accelerated ubiquitination and degradation of CD147, which downregulated the expres-sion of SREBP1c. In addition, overexpression of FBXO31 resulted in the reduction of lipogenesis through suppressing the activation of AKT/mTOR signaling axis, thus preventing the tumor growth and aggressiveness in glioma. These results provided a new cognition to pathology of glioma and new therapeutic targets for treating glioma in future.

• 单位
  哈尔滨医科大学