An idle PHGDH takes control of cell fate

摘要

Multifunctional metabolites are widely involved in physiological and pathological processes as signaling molecules, sensors, epigenetic modification substrates and so on, in addition to being energy substances. In a recent Cell Research study, Wu et al. make a remarkable discovery that, when the level of 3-phosphoglycerate, a typical metabolite at the crossroads of glucose catabolism and serine anabolism, is low, the unoccupied 3-phosphoglycerate dehydrogenase is redirected to watch the cell fate.

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