A Honeycomb-Like Bismuth/Manganese Oxide Nanoparticle with Mutual Reinforcement of Internal and External Response for Triple-Negative Breast Cancer Targeted Therapy

作者：Xu, Xingyi; Zhang, Rongyuan; Yang, Xianfeng; Lu, Yao; Yang, Zhongmin; Peng, Mingying; Ma, Zhijun^*; Jiao, Ju^*; Li, Lihua^*

来源：Advanced Healthcare Materials, 2021, 10(18): 2100518.

DOI：10.1002/adhm.202100518

• high payloads
• honeycomb-like nanoparticles
• mutual reinforcement
• smart responsive materials
• triple-negative breast cancer

Triple-negative breast cancer (TNBC) exhibits aggressive behavior and high levels of metastasis owing to its complex heterogeneous structure and lack of specific receptors. Here, tumor cell membrane (CM)-coated bismuth/manganese oxide nanoparticles (NPs) with high indocyanine green (ICG) payload up to 50.6 wt% (mBMNI NPs) for targeted TNBC therapy are constructed. The extra-high drug load Bi@Bi2O3@MnOx NPs (honey-comb like structure) are formed by Kirkendall effect and electrostatic attraction. After modified with CM, they can home into tumor sites precisely, where they respond to internal overexpressed glutathione (GSH), releasing Mn2+ for chemodynamic therapy (CDT) with GSH depletion, while H2O2 degrades into O-2 enabling relief of tumor hypoxia. In response to external near-infrared irradiation, mBMNI NPs intelligently generate vigorous heat and single oxygen (O-1(2)) for photothermal therapy (PTT) and photodynamic therapy (PDT) owing to high load. Importantly, O-2 production and GSH consumption during the internal response reinforce external PDT, while the heat generated through PTT during the external response promotes internal CDT. The honeycomb-like structure with high ICG load and mutual reinforcement between internal and external response results in excellent therapeutic effects against TNBC.

• 单位
  1; 苏州大学; 南方医科大学; 中山大学