Cascade Synthesis from Cyclohexane to ε-Caprolactone by Visible-Light-Driven Photocatalysis Combined with Whole-Cell Biological Oxidation

作者：Li, Peilin; Ma, Yunjian; Li, Yongru; Zhang, Xizhen; Wang, Yonghua^*

来源：Chembiochem : a European journal of chemical biology , 2020, 21(13): 1852-1855.

DOI：10.1002/cbic.202000035

• biocatalysis
• cascade reactions
• oxy-functionalization
• photooxidation
• whole cells

Cyclohexane was directly oxy-functionalised to epsilon-caprolactone through a cascade reaction sequence combining visible-light-driven photocatalysis with cyclohexanone monooxygenase (CHMO) whole-cell biocatalysis. Two available photocatalysts, Au-doped TiO2(Au-TiO2) and graphitic carbonitride (g-C3N4), were evaluated in the experiment and some optimisations to the cascade reaction were applied. In stepwise mode, the highest degree of conversion from cyclohexanol to epsilon-caprolactone can be up to 41 %, with use of g-C3N4. The cascade reaction from cyclohexane to epsilon-caprolactone is achievable under a light intensity of 149 mu W cm(-2).