Association between systolic blood pressure and first ischemic stroke in the Chinese older hypertensive population

作者：Yu, Yuling; Liu, Lin; Huang, Jiayi; Shen, Geng; Chen, Chaolei; Huang, Yuqing; Zhang, Bin; Tang, Songtao; Feng, Yingqing^*

来源：Journal of International Medical Research, 2020, 48(4): 0300060520920091.

DOI：10.1177/0300060520920091

• Systolic blood pressure
• ischemic stroke
• community
• older population
• hypertension
• cardiovascular risk

Objective @@@ This study aimed to evaluate the association between systolic blood pressure (SBP) and first ischemic stroke in older people with hypertension in the community. @@@ Methods @@@ This retrospective cohort study included 3315 residents who were hypertensive and older than 60 years in Guangdong, China. @@@ Results @@@ A total of 1475 men and 1840 women aged 71.41 +/- 7.20 years were included. All subjects had a median follow-up duration for 5.5 years and 206 subjects reached the endpoint. The prevalence of first ischemic stroke increased with a higher SBP. SBP expressed as a continuous variable (hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.00-1.02) and categorical variable (HRs, 1.00, 1.06, 1.17, 1.39, and 1.60 for increasing blood pressure from < 120->= 150 mmHg), was significantly associated with a higher risk of first ischemic stroke. Moreover, a fully adjusted model indicated an obvious increased risk in the SBP >= 150 mmHg group (HR, 1.60; 95% CI, 1.15-2.71) and the SBP 140-149 mmHg group (HR, 1.39; 95% CI, 1.01-2.39). @@@ Conclusions @@@ High SBP was independently associated with the risk of first ischemic stroke in hypertensive residents in the community aged older than 60 years. SBP >= 140 mmHg increases the risk of first ischemic stroke.

• 单位
  广东省人民医院; 广东省心血管病研究所; 南方医科大学