科研之友
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摘要
Objective To observe the efficacy and safety of Vitamin A palmitate eye ophthalmic gel for the treatment of dry eye.Methods Totally 57 dry eye patients (57 eyes) enrolled in our hospital from February 2015 to December 2015 were randomly divided into three groups∶ group A,Vitamin A palmitate eye ophthalmic gel;group B,0.1％ Ellie eye drops;group C,Vitamin A palmitate eye ophthalmic gel combined with Ellie eye drops.Each eye drops was used 4 times a day.Ocular surface disease index (OSDI),lissamine green staining,fluorescent staining (FL),tear break-up time (BUT),Schirmer I test and conjunctival impression cytology (IC) was observed in these patients before the treatment,in 2 weeks and 4 weeks after treatment.The mean of the results were compared by Paired t test and One-Way ANOVA.Results After 2 weeks of the treatment,the mean score of OSDI was significantly lower than that before the treatment in group A and C (P ＜0.05).After 4 weeks of the treatment,the mean score of OSDI was the lowest in group C.The lissamine green staining and FL in group A and C were significantly lower than that before the treatment (P ＜0.05).Furthermore,the lissamine green staining in group C was significantly lower than group B.After 4 weeks of the treatment,the mean score of ST in group A and C was significantly expanded than that before the treatment (P ＜0.05) and those two groups were significantly expanded than group B.There were 9 mild dry eye patients in group C.After 4 weeks of the treatment,the average density of the goblet cells in these patients were significantly increased than that before the treatment (P ＜0.05).Conclusions Topical Vitamin A palmitate eye ophthalmic gel combined Ellie eye drops is safe and effective for the treatment of dry eye.
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单位中山大学
