Wearable sensors for real-time physiological monitoring based on self-assembled diphenylalanine peptide nanostructures

作者：Ravikumar, Ayyanu; Natraj, Vishal; Verma, Adarsh; Sivagnanam, Subramaniyam; Sivalingam, Yuvaraj^*; Das, Priyadip^*; Surya, Velappa Jayaraman; Han, WeiHua; Liu, Nan^*

来源：Surfaces and Interfaces, 2023, 39: 102986.

DOI：10.1016/j.surfin.2023.102986

• Self -assembly
• Diphenylalanine peptides
• Piezoelectric nanogenerator
• Biomechanical actions
• Physiological monitoring

Self-assembled diphenylalanine short peptides show great potential in wearable and flexible biomedical devices due to its excellent biocompatibility and piezoelectric nature. Herein, the piezoelectric activity of self-assembled diphenylalanine analogues by rationally selecting chemical linkers such as ethylene diamine, succinic acid and terephthalaldehyde. Our results show that the self-assembled diphenylalanine with terepthalaldehyde linker has a favorable effect on the piezoelectric activity. The output of an optimized SP3 PNG can reach 29 V and 480 nA, and, it has exhibited excellent stability, repeatability, and charging-discharging capacity. Such a device can be used to harness energy or detect biomechanical actions such as swallowing, finger bending, coughing, posture angle monitoring and alphabet recognition. The PNG has been used to monitor arterial pulses as a biomedical application model. The obtained results are steppingstones towards developing robust bio-implantable PNGs for powering pacemakers and implantable cardioverter-defibrillators (ICDs) in future.

• 单位
  南方医科大学; 江苏大学; y; 兰州大学