circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-kB axis

作者：Ai, Yilong; Song, Jing; Wei, Haigang; Tang, Zhe; Li, Xia; Lv, Xiaozhi; Luo, Hailing; Wu, Siyuan^*; Zou, Chen^*

来源：Biochemical and Biophysical Research Communications, 2021, 566: 108-114.

DOI：10.1016/j.bbrc.2021.06.009

• Circ_0001461
• miR-145
• TLR4
• Oral squamous cell carcinoma

Circular RNAs (circRNAs) have been widely reported to participate in progression of various cancers, including oral cancer. Previous study showed circ_0001461 was aberrantly expressed in oral squamous cell carcinoma (OSCC), while its role in tumorigenesis of OSCC remains largely unclear. In this study, we confirmed that circ_0001461 was highly expressed in OSCC cell lines and tumor tissues. Knocking down of circ_0001461 suppressed cell proliferation, migration and invasion in vitro, and repress xenograft tumor growth in vivo. Mechanistically, we found circ_0001461 regulates OSCC cell proliferation, migration and invasion through sponging miR-145. Furthermore, circ_0001461 promotes the resistance of TNF-a-induced apoptosis of OSCC cells by modulating miR-145/TLR4/NF-kB pathway. In general, our study demonstrated a novel regulatory mechanism that circ_0001461/miR-145/TLR4/NF-kB axis modulates oral squamous cell carcinoma progression.

• 单位
  南方医科大学; 佛山科学技术学院