Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis

作者：Gao, Zhiguang^*; Yang, Jingge; Liang, Yuzhi; Yang, Sen; Zhang, Tao; Gong, Zuyuan; Li, Min

来源：Obesity Surgery, 2022, 32(8): 2706-2716.

DOI：10.1007/s11695-022-05959-4

• Roux-en-Y gastric bypass
• Gastric inhibitory polypeptide
• GIP
• Meta-analysis

This meta-analysis aimed to evaluate changes in GIP after RYGB in obese patients. We searched PubMed, EMBASE, and CENTRAL for relevant studies from database inception through July 2021. Articles were eligible for inclusion if they reported pre-operative and post-operative fasting GIP levels. We found fasting GIP levels had a decreasing tendency. The decrease in fasting glucose and postprandial GIP levels was also observed. Subgroup analysis indicated diabetic subjects tended to have a more obvious fasting GIP reduction compared to non-diabetic individuals. Meta-regression showed that the amount of weight loss (% total body weight), gastric pouch volume, alimentary limb length, and biliopancreatic limb length were not related to fasting GIP decrease. Fasting GIP levels decreased significantly after RYGB in obese people, especially in diabetic patients.

• 单位
  1; 南方医科大学; 广东医学院