Inhibitory of EV-A71 virus-induced apoptosis by ZVAD through ROS mediated signaling pathways

Authors：Xu, Tiantian; Zheng, Ruilin; Chen, Danyang; Chen, Haiyang; Zhao, Mingqi; Guo, Min; Chen, Yi; Wang, Changbing; Kuang, Lu; Li, Yinghua^*; Zhu, Bing^*

Source：BIOCELL, 2022, 46(4): 1033-1039.

DOI：10.32604/biocell.2022.017757

• ZVAD
• EV-A71 virus
• ROS
• Apoptosis

Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating ROS mediated signaling pathway and inflammation cytokines to achieve antiviral.

• Institution
  中国医科大学; 南方医科大学