Fabrication of Redox-Controllable Bioinspired Nanochannels for Precisely Regulating Protein Transport

作者：Tu, Le; Qiu, Sheng; Li, Yuntao; Chen, Xiaoya; Li, Junrong^*; Xiong, Xiaoxing^*; Sun, Yao^*; Han, Yunfeng; Li, Haibing

来源：ACS applied materials & interfaces, 2022, 14(23): 27421-27426.

DOI：10.1021/acsami.2c05594

• bioinspired nanochannel
• protein transport
• redox driven
• pillar[5]arene
• gating ratio

Redox regulation is an inherent feature of nature and plays a crucial role in the transport of ions/small molecules. However, whether redox status affects the biomolecule transport remains largely unknown. To explore the effects of redox status on biomolecule transport, herein, we constructed a glutathione/glutathione disulfide (GSH/GSSG)-driven and pillar[5]arene (P5)-modified artificial nanochannel for protein transport. The results indicate that hemoglobin (Hb) protein is selectively and effectively transported across the GSH-driven P5-modified nanochannel, which suggests that the redox status of the nanochannel could affect the process of protein transport. Therefore, this redox-driven nanochannel could provide a potential application for biomolecule detection and redoxcontrollable biomolecular drug release.

• 单位
  华中科技大学; y; 浙江大学; 武汉大学