The U-Shape Relationship Between Glycated Hemoglobin Level and Long-Term All-Cause Mortality Among Patients With Coronary Artery Disease

作者：Liu, Liwei; Ye, Jianfeng; Ying, Ming; Li, Qiang; Chen, Shiqun; Wang, Bo; Lin, Yihang; Chen, Guanzhong; Lun, Zhubin; Huang, Haozhang; Li, Huangqiang; Xu, Danyuan; Tan, Ning; Chen, Jiyan; Liu, Jin^*; Liu, Yong^*

来源：Frontiers in Cardiovascular Medicine, 2021, 8: 632704.

DOI：10.3389/fcvm.2021.632704

• coronary artery disease
• glycated hemoglobin
• all-cause mortality
• U-shape
• optimal

Background: Although glycated hemoglobin (HbA1c) was considered as a prognostic factor in some subgroup of coronary artery disease (CAD), the specific relationship between HbA1c and the long-term all-cause death remains controversial in patients with CAD. @@@ Methods: The study enrolled 37,596 CAD patients and measured HbA1c at admission in Guangdong Provincial People's Hospital. The patients were divided into 4 groups according to HbA1c level (Quartile 1: HbA1c <= 5.7%; Quartile 2: 5.7% < HbA1c <= 6.1%; Quartile 3: 6.1% < HbA1c <= 6.7%; Quartile 4: HbA1c > 6.7%). The study endpoint was all-cause death. The restricted cubic splines and cox proportional hazards models were used to investigate the association between baseline HbA1c levels and long-term all-cause mortality. @@@ Results: The median follow-up was 4 years. The cox proportional hazards models revealed that HbA1c is an independent risk factor in the long-term all-cause mortality. We also found an approximate U-shape association between HbA1c and the risk of mortality, including increased risk of mortality when HbA1c <= 5.7% and HbA1c > 6.7% [Compared with Quartile 2, Quartile 1 (HbA1c <= 5.7), aHR = 1.13, 95% CI:1.01-1.26, P < 0.05; Quartile 3 (6.1% < HbA1c <= 6.7%), aHR = 1.04, 95% CI:0.93-1.17, P =0.49; Quartile 4 (HbA1c > 6.7%), aHR = 1.32, 95% CI:1.19-1.47, P < 0.05]. @@@ Conclusions: Our study indicated a U-shape relationship between HbA1c and long-term all-cause mortality in CAD patients.

• 单位
  广东省心血管病研究所; 南方医科大学; 广东省人民医院; y