Role of HMGB1 in the formation of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism

作者：Li, M.; Zhao, X. -Y.; Kou, Y.^*; Kou, J. -J.^*

来源：European Review for Medical and Pharmacological Sciences, 2022, 26(20): 7605-7615.

• Key HMGB1
• PE
• CTEPH
• Neutrophil extracellular traps
• Inflammation

Acute pulmonary embolism (PE) may be a common but fatal condition in sever-al countries; in untreated or inadequately ther-apeutic PE patients, is a commonly occurring long-term complication affecting patient surviv-al treatment and prognosis, contributing to right heart disease and may even be fatal. To date, the pathogenesis of chronic thromboembolic pul-monary hypertension (CTEPH) due to acute pulmonary embolism remains unclear; hence, there is an immediate demand for medications that are directly aimed at both preventing and managing the progression of CTEPH. Previous studies have shown that the inflammatory response is associated with thrombosis and the devel-opment of pulmonary cardiovascular disease. High-mobility Group B 1 (HMGB1), a damage -as-sociated molecular pattern (DAMP), is involved in deep vein thrombosis and inflammatory reactions, vascular remodeling, and thrombosis in pulmonary hypertension. Therefore, we hypoth-esized that HMGB1 participates in the process of CTEPH development after acute PE. This pa-per details the dynamic changes in HMGB1 and the relationship between HMGB1 and the ad-vancement of CTEPH after acute PE to better un-derstand the pathogenic mechanisms and po-tential clinical applications.

• 单位
  y; 哈尔滨医科大学