Rh(iii)-Catalyzed Csp2-Csp3 bond alkoxylation of α-indolyl alcohols via C-C σ bond cleavage

Authors：Yang, Can; Liu, Zhipeng; Hu, Xinwei; Xie, Haisheng; Jiang, Huanfeng; Zeng, Wei^*

Source：Organic Chemistry Frontiers, 2021, 8(12): 2949-2954.

DOI：10.1039/d1qo00194a

A Rh(iii)-catalyzed direct Csp(2)-Csp(3) bond alkoxylation of alpha-(2-indolyl)alcohols with alcohols has been reported. This transformation features a rapid C-C sigma bond/C-O single bond switch, and provides a novel approach for assembling 2-alkoxylindole skeletons. A catalytic cycle involving a beta-aryl elimination process is proposed.