Effects of atorvastatin and rosuvastatin on dysfunctional coronary circulation in patients with ST-segment elevation myocardial infarction

作者：Zhou, Langping; Hu, Xiangming; Zhang, Haotian; Lu, Haoyu; Lin, Yan; Wang, Weimian; Yu, Bingyan; Liang, Wensheng; Zhou, Yingling; Li, Guang; Dong, Haojian^*

来源：Journal of International Medical Research, 2023, 51(6): 03000605231182547.

DOI：10.1177/03000605231182547

• Atorvastatin
• rosuvastatin
• ST-segment elevation myocardial infarction
• high thrombus burden
• coronary circulation
• primary percutaneous coronary intervention

ObjectiveEvidence of therapy for dysfunctional coronary circulation in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) is limited. This study was performed to compare the effects of atorvastatin and rosuvastatin on dysfunctional coronary circulation. MethodsThis retrospective study enrolled 597 consecutive patients with STEMI who underwent pPCI in 3 centers from June 2016 to December 2019. Dysfunctional coronary circulation was defined by the thrombolysis in myocardial infarction (TIMI) grade and the TIMI myocardial perfusion grade (TMPG). Logistic regression analysis was used to evaluate the impact of different statin types on dysfunctional coronary circulation. ResultsThe incidence of TIMI no/slow reflow did not differ between the two groups, but the incidence of TMPG no/slow reflow was significantly lower in the atorvastatin than rosuvastatin group (44.58% vs. 57.69%, respectively). After multivariate adjustment, the odds ratio with 95% confidence interval of rosuvastatin was 1.72 (1.17-2.52) for after pretreatment TMPG no/slow reflow and 1.73 (1.16-2.58) for after stenting TMPG no/slow reflow. Atorvastatin and rosuvastatin showed no significant differences in clinical outcomes during hospitalization. ConclusionsCompared with rosuvastatin, atorvastatin was associated with better coronary microcirculatory perfusion in patients with STEMI who underwent pPCI.

• 单位
  广东省人民医院; 汕头大学; 广东省心血管病研究所; 南方医科大学