A Six Coordinated Phosphorus(V) Corrole Bearing Two Hydroxyl Axial Ligands: X-Ray Structure, DNA Interaction, Photonuclease Activity, and Cytotoxicity towards Tumor Cells

作者：Jiang, Xiao; Sun, Yan-Mei; Cen, Jing-He; Yang, Wu; Liao, Yu-Hui^*; Shi, Lei^*; Lin, Dong-Zi; Liu, Hai-Yang^*

来源：ChemistrySelect, 2021, 6(32): 8200-8204.

DOI：10.1002/slct.202101974

• Corrole
• Cytotoxicity
• DNA
• Phosphorus
• Photodynamic therapy

Phosphorus corrole has been explored as a promising photosensiter for photodynamic therapy (PDT) treatment in decade. A new trans-bishydroxyl axial ligated phosphorus(V) 5, 15-bis(pentafluorophenyl)-10(p-hydroxylphenyl) corrole (1-P) was synthesized and well characterized by X-ray structure determination. Complex 1-P could bind ct-DNA via an outside binding mode and displayed good photonuclease activity. After illumination, it might significantly generate singlet oxygen, hydroxyl radical and superoxide anion radical. 1-P exhibited low dark toxicity but high photocytotoxicity against HepG2, CNE-2, A549 and MDA-MB-231 tumor cell lines. Preliminary results show 1-P is a promising candidate of PDT photosensitizer.

• 单位
  广东教育学院; 南方医科大学