Bioactive constituents from the leaves of Croton tiglium

作者：Jiang, Zhi-Yong^*; Duan, Li-Kun; Feng, Jin-E; Liu, Chun-Jiang; Li, Xiao-Fei; Li, Yuan; Huang, Chun-Qiu; Shi, Sheng-Li; Zuo, Ai-Xue^*; He, Hong-Ping^*

来源：Phytochemistry Letters, 2022, 49: 65-72.

DOI：10.1016/j.phytol.2022.03.003

• Croton tiglium
• Phorbol esters
• Sesquiterpenoids
• Larvicidal activity
• a-glucosidase inhibitory activity

Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and alpha-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 mu g/mL, while the sesquiterpenoids 11 and 15 showed noticeable alpha-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 mu M, respectively.

• 单位
  云南大学