Effects of age, sex, and sertraline administration on seizure-induced respiratory arrest in the DBA/1 mouse model of sudden unexpected death in epilepsy (SUDEP)

作者：Faingold C L^*; Randall M

来源：Epilepsy and Behavior, 2013, 28(1): 78-82.

DOI：10.1016/j.yebeh.2013.04.003

• Age
• DBA/1 mice
• Development
• Respiratory arrest
• Sertraline
• Sex
• SSRI
• SUDEP

DBA/1 mice are susceptible to audiogenic seizure-induced respiratory arrest (S-IRA), leading to death, which is a model of human sudden unexpected death in epilepsy (SUDEP). Female DBA/1 mice exhibited 71 susceptibility to S-IRA on the third daily test when seizure testing began at postnatal day (PND) 24-30, which was slightly (>. 10) but not significantly lower than males. When initial seizure testing was delayed (to >. 7. weeks of age), DBA/1 mice of both sexes exhibited significantly reduced S-IRA susceptibility, as compared to mice tested initially at PND 24-30. These sex and age issues had not been previously evaluated and may be important for the future use of this SUDEP model. We also observed that 30. min after administering a selective serotonin reuptake inhibitor (SSRI), sertraline (40, 50, or 75. mg/kg i.p.), a significantly reduced S-IRA incidence in DBA/1 mice occurred without blocking seizures, which may be relevant to SUDEP prevention.

• 单位
  Southern Illinois University; United States