Reduction of the trans-cortical vessel was associated with bone loss, another underlying mechanism of osteoporosis

作者：Xiao, Chun-Lin; Liu, Lu-Lin; Tang, Wen; Liu, Wu-Yang; Wu, Long-Yan^*; Zhao, Kai^*

来源：Microvascular Research, 2024, 152: 104650.

DOI：10.1016/j.mvr.2023.104650

• TCVs
• Bone mass
• Osteoporosis
• Microvascular disease

Rationale: Numerous studies have established a robust association between bone morrow microvascular diseases and osteoporosis. This study sought to investigate the relationship between alterations in trans-cortical vessel (TCVs) and the onset of osteoporosis in various mouse models.Methods: Aged mice, ovariectomized mice, and db/db mice, were utilized as osteoporosis models. TCVs in the tibia were detected using tissue clearing and light sheet fluorescence microscopy imaging. Femurs bone mass were analyzed using micro-CT scanning. Correlations between the number of TCVs and bone mass were analyzed using Pearson correlation analysis.Results: All osteoporosis mouse models showed a significant reduction in the number of TCVs compared to the control group. Correlation analysis revealed a positive association between the number of TCVs and bone mass. TCVs were also expressed high levels of CD31 and EMCN proteins as type H vessels.Conclusions: This study underscores a consistent correlation between the number of TCVs and bone mass. Moreover, TCVs may serve as a potential biomarker for bone mass evaluation.

• 单位
  1; 南方医科大学