Copper-promoted cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines using a peroxide-driven radical reductive strategy

作者：Jiang, Hui-Min; Qin, Jing-Hao; Sun, Qing; Zhang, Dong; Jiang, Jin-Peng; Ouyang, Xuan-Hui^*; Song, Ren-Jie^*; Li, Jin-Heng^*

来源：Organic Chemistry Frontiers, 2022, 9(15): 4070-4077.

DOI：10.1039/d2qo00706a

• HANTZSCH ESTERS
• TRANSFER HYDROGENATION
• MECHANISTIC ASPECTS
• METAL-FREE
• AMINATION
• ALKYLATION
• PHOTOREDOX
• ALDEHYDES
• KETONES
• AMINES

A copper-promoted reductive cross-coupling of nitroarenes with 4-alkyl-1,4-dihydropyridines for producing N-alkylbenzenamines is described. Using 4-alkyl-1,4-dihydropyridines as alkyl radical sources and internal reducing agents enables the construction of C(sp(3))-N bonds under oxidative conditions, which provide an elegant complementary platform to assemble N-alkylbenzenamines with good tolerance for sensitive functional groups.

• 单位
  南昌航空大学; 兰州大学