科研之友
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摘要
A protocol for FeCl2-catalyzed oxidative decarbonylative alpha-alkylation of acyl furans using alkyl aldehydes as the alkylating agents has been developed. This protocol affords alpha-alkyl-alpha-acylfurans in moderate to good yields in a practical and sustainable fashion. Mechanistic studies suggest that the reaction proceeds via generation of an alkyl radical from the alkyl aldehyde, addition of the radical to the furan ring, and subsequent rearomatization.
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单位广州中医药大学
