A Co(II)-Schiff Base Complex: Crystal Structure and Application Values on SARS-COV-2 Induced Acute Lung Injury

作者：Qin, You-Fa^*; Deng, Tao; Li, Cui-E; Lu, Jun; Zhu, Yong-Kun

来源：Latin American Journal of Pharmacy, 2021, 40(10): 2527-2531.

• acute lung injury
• coordination complex
• RT-PCR

In the present study, a new Co(II)-Schiff base complex, [Co(HL)(2)Cl-2] (1), [Schiff base (HL) = 2-(2-methoxybenzylideneamino)phenol] has been successfully prepared by reaction of Co(II) chloride hexahydrate with the Schiff base ligand HL in a mixed solvent of aqueous-methanolic solution via a slow evaporation synthesis method. For the treatment of SARS-COV-2 induced acute lung injury, the ELISA detection kit was performed in the research to measure the content of inflammatory cytokines TNF-alpha and IFN-gamma released into the alveolar lavage fluid. In addition to this, the activation levels of the prolyl carboxypeptidase in the alveolar epithelial cells were determined with real time RT-PCR.

• 单位
  中国科学院; 南方医科大学