Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy

Authors：Qi, Pengyuan; Luo, Cheng; Pan, You; Ding, Shuaijie; Li, Xiang^*; Qiao, Kun^*; Ning, Shipeng^*

Source：Colloids and Surfaces B: Biointerfaces , 2023, 227: 113347.

DOI：10.1016/j.colsurfb.2023.113347

• Single-atom nanozyme
• Glucose oxidase
• Low-dose radiotherapy
• Cascade catalysis

Radiotherapy (RT) efficacy can be promoted with the help of nanoenzyme that can "re-programing" the tumour's micro-environment by changing the expression level of special bio-molecules. However, problems such as low reaction efficiency, limited endogenous H2O2, and/or unsatisfactory results of a single catalysis mode in treatment limit the application in the RT field. Herein, a novel Au nanoparticles (AuNPs) decorated iron SAE (FeSAE@Au) was formulated for self-cascade catalytic RT. In this dual-nanozyme system, embedded AuNPs can sever as GOx and endow FeSAE@Au with self-H2O2 supplying ability, which can elevate the H2O2 level in tumors by catalyzing cellular glucose in situ, further improving the catalytic performance of FeSAE with peroxidase-like activity. The self-cascade catalytic reaction can significantly increase cellular hydroxyl radicals (& BULL;OH) level, further promoting RT's effect. Furthermore, in vivo findings demonstrated that FeSAE can effectively limit tumor growth while causing low damage in important organs. According to our understanding, FeSAE@Au is the first description of a hybrid SAE-based nanomaterial employed in cascade catalytic RT. The research yields new and interesting insights for developing various SAE systems for anticancer therapy.

• Institution
  1; 华中科技大学; 哈尔滨医科大学