Two new gamma-pyrone glucosides from Paeonia albiflora

作者：Chen Shao Dan; Wang Dong Mei; Lu Chuan Jian^*; Zhao Rui Zhi

来源：Journal of Asian Natural Products Research, 2016, 18(2): 153-158.

DOI：10.1080/10286020.2015.1082548

• gamma-pyrone glucosides
• chemical constituents
• Paeonia albiflora

Two new gamma-pyrone glucosides, along with three known compounds, were isolated from the roots of Paeonia albiflora, and their structures were elucidated by spectral experiments, chemical analysis, and comparison with literature data. The structures of the new compounds were established as 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside (1), and 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6-O-galloyl-beta-D-glucopyranoside (2). The inhibitory activity on the release of TNF-alpha of compounds 1-5 was evaluated in vitro. This is the first report of the presence of gamma-pyrone glucoside in P. albiflora.

• 单位
  广东省微生物研究所; 广州中医药大学; 广东省中医研究所