Personalized Bacteria Loaded with Autoantigens for the Enhancement of Tumor Immunotherapy

作者：Wu, Chenghu; He, Wenjuan; Chen, Yue; Cai, Jie; Zeng, Fanjun^*; Lu, Zidong^*; Wang, Jilong^*

来源：Advanced Healthcare Materials, 2023, 12(11).

DOI：10.1002/adhm.202203026

• engineered Salmonella
• personalized immunotherapy
• polydopamine nanoparticles
• whole tumor antigens

Currently, tumor immunotherapy is becoming a new revolution in tumor treatment. Generated from tumor cell lysate (TCL) or irradiated tumor cells, the whole tumor antigen-based vaccines have the possibility to enhance antitumor immune response without survival from immune surveillance in personalized immunotherapy. Here, polydopamine nanoparticles (PDA NPs) after self-polymerization are covalently coated with TCL to form PDA@CL. Engineered Salmonella (EnS) wrapped with PDA@CL (EnS@PDA@CL) is targeted the localization of the tumor site by intravenous administration. EnS@PDA@CL delivered autologous antigen-containing nanoparticles to tumor hypoxia regions through blood circulation. The PDA@CL particles promote the maturation of dendritic cells (DCs), thus eliciting the infiltration of whole tumor antigens specific cytotoxic T lymphocytes, significantly triggering antitumor immunity. The tumor regression in the Panc02 mice confirms the therapeutic potential of EnS@PDA@CL in clinical personalized immunotherapy.

• 单位
  安徽医科大学; 广东省人民医院; 中国科学院研究生院