Hypouricemic Actions of the Pericarp of Mangosteen in Vitro and in Vivo

摘要

Hyperuricemia is the result of overproduction and/ or underexcretion of uric acid, and it is a well-known risk factor for gout, hypertension, and diabetes. However, available drugs for hyperuricemia in the clinic are limited. Recently, a lot of research has been conducted in order to discover new uric acid-lowering agents from plants and foods. We found that the extracts from the pericarp of mangosteen reduced urate. Bioactivity-guided study showed that alpha-mangostin was the principal constituent. Herein, we reported for the first time the hypouricemic activities and underling mechanism of alpha-mangostin. The alpha-mangostin dose-and time-dependently decreased the levels of serum urate in hyperuricemic mice and markedly increased the clearance of urate in hyperuricemic rats, exhibiting a promotion of urate excretion in the kidney. Further evidence showed that alpha-mangostin significantly decreased the protein levels of GLUT9 in the kidneys. The change in the expression of URAT1 was not observed. Moreover, alpha-mangostin did not inhibit the activities of xanthine oxidoreductase and uricase in vitro or in vivo. Taken together, these findings suggest that alpha-mangostin has potential to be developed as a new anti-hyperuricemic agent with promoting uric acid excretion.

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