η6-Arene CH-O Interaction Directed Dynamic Kinetic Resolution - Asymmetric Transfer Hydrogenation (DKR-ATH) of α-Keto/enol-Lactams

作者：Luo, Zhonghua; Sun, Guodong; Wu, Shuming; Chen, Yong; Lin, Yicao; Zhang, Lei^*; Wang, Zhongqing^*

来源：Advanced Synthesis and Catalysis, 2021, 363(12): 3030-3034.

DOI：10.1002/adsc.202100288

• Dynamic kinetic resolution-asymmetric transfer hydrogenation
• enatioselectivity
• lactams
• CH-O interaction
• mechanism

A dynamic kinetic resolution - asymmetric transfer hydrogenation (DKR-ATH) methodology of alpha-keto/enol-lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by eta(6)-arene CH-O interaction. The efficient approach can be applied to a wide range of substrates including non-aryl ones which would be difficult to prepare by other asymmetric reduction methods.