Anti-inflammatory catecholic chitosan hydrogel for rapid surgical trauma healing and subsequent prevention of tumor recurrence

作者：Gang He; Xu Yan; Zhaohua Miao; Haisheng Qian; Yan Ma; Yan Xu; Li Gao; Yang Lu; Zhengbao Zha

来源：CHINESE CHEMICAL LETTERS, 2020, 31(7): 1807-1811.

• Surgery
• Anti-inflammation
• Bactericidal capacity
• Trauma healing
• Tumor recurrence

Although occupying pillar position in clinical cancer treatments,surgery itself and surgical trauma would elicit series of local/systemic inflammation-related responses that resulted in high rate of tumor recurrence.Herein,chitosan with conjugated gallic acid (CSG) molecules were coordinated with Fe3+ to form CSG/Fe3+ hydrogel for filling the tumor-resected cavity with considerable wet-adhesion ability and anti-inflammatory performance.With the assistance of doxorubicin hydrochloride (DOX·HCI),CSG/Fe3+/DOX hydrogel exhibited synergistic photothermal-chemo tumor-inhibited performance under near-infrared (NIR) light irradiation for eradicating residual and/or surgical trauma-recruited cancer cells.Thus,our study attempts to show a paradigm that realizes quick surgical trauma healing,inflammation inhibition and prevention of postsurgical tumor recurrence.

• 单位
  安徽医科大学; 合肥工业大学