Construction of a pH- and near-infrared irradiation-responsive nanoplatform for chemo-photothermal therapy

作者：Gao, Qiang; Gao, Jun^*; Ding, Chengqiang; Li, Shangji; Deng, Linhong; Kong, Yong^*

来源：International Journal of Pharmaceutics, 2021, 593: 120112.

DOI：10.1016/j.ijpharm.2020.120112

• Nanoplatform
• Photocatalytic reduction
• pH-Sensitivity
• Near-infrared irradiation
• Chemo-photothermal therapy

Au nanoclusters, decorated with graphene quantum dots (GQDs), were obtained through photocatalytic reduction of AuCl43- by UV irradiation, and then cytarabine (Cyt) was loaded to the Au/GQDs via charge-dipole interactions. Mercaptopropionic acid (MPA) was anchored to the Cyt-loaded Au/GQDs through the formation of Au-S bond, which was further encapsulated by polyethyleneimine (PEI) via charge-dipole interactions. The delivery of Cyt from the quaternary complex (Au/GQDs/MPA/PEI) is pH-sensitive and can be modulated by near-infrared (NIR) irradiation. The results of cell viability test indicate that the developed nanoplatform can be used for chemo-photothermal combination therapy of cancer cells, and the efficacy of chemo-photothermal combination therapy is significantly higher than that of the single mode of photothermal therapy (PTT) or chemotherapy.

• 单位
  常州大学; 1; y