A three-dimensional printing navigational template combined with mixed reality technique for localizing pulmonary nodules

作者：Fu, Rui; Zhang, Chao; Zhang, Tao; Chu, Xiang-Peng; Tang, Wen-Fang; Yang, Xue-Ning; Huang, Mei-Ping; Zhuang, Jian; Wu, Yi-Long; Zhong, Wen-Zhao^*

来源：Interactive Cardiovascular and Thoracic Surgery, 2021, 32(4): 552-559.

DOI：10.1093/icvts/ivaa300

• Pulmonary nodules
• Ground glass opacity
• Lung cancer
• Three-dimensional printing
• Mixed reality

OBJECTIVES: Localizing non-palpable pulmonary nodules is challenging for thoracic surgeons. Here, we investigated the accuracy of three-dimensional (3D) printing technology combined with mixed reality (MR) for localizing ground glass opacity-dominant pulmonary nodules. @@@ METHODS: In this single-arm study, we prospectively enrolled patients with small pulmonary nodules (<2 cm) that required accurate localization. A 3D-printing physical navigational template was designed based on the reconstruction of computed tomography images, and a 3D model was generated through the MR glasses. We set the deviation distance as the primary end point for efficacy evaluation. Clinicopathological and surgical data were obtained for further analysis. @@@ RESULTS: Sixteen patients with 17 non-palpable pulmonary nodules were enrolled in this study. Sixteen nodules were localized successfully (16/17; 94.1%) using this novel approach with a median deviation of 9 mm. The mean time required for localization was 25 +/- 5.2 min. For the nodules in the upper/middle and lower lobes, the median deviation was 6 mm (range, 0-12.0) and 16 mm (range, 15.0-20.0), respectively. The deviation difference between the groups was significant (Z = -2.957, P = 0.003). The pathological evaluation of resection margins was negative. @@@ CONCLUSIONS: The 3D printing navigational template combined with MR can be a feasible approach for localizing pulmonary nodules.

• 单位
  汕头大学; 广东省心血管病研究所; 广东省人民医院