The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity

作者：Xu, Luyao; Li, Lingyue; Chen, Qianling; Huang, Yuebing; Chen, Xuebing^*; Qiao, Dongfang^*

来源：Cellular and Molecular Neurobiology, 2023, 43(6): 2415-2436.

DOI：10.1007/s10571-023-01323-x

• Brain region specificity
• Methamphetamine (METH)
• Non-coding RNA (ncRNA)
• Methamphetamine-related psychiatric disorders
• Neurotoxicity

Methamphetamine (METH) is an amphetamine-type stimulant that is highly toxic to the central nervous system (CNS). Repeated intake of METH can lead to addiction, which has become a globalized problem, resulting in multiple public health and safety problems. Recently, the non-coding RNA (ncRNA) has been certified to play an essential role in METH addiction through various mechanisms. Herein, we mainly focused on three kinds of ncRNAs including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxicity effects such as cognitive impairment, behavioral abnormalities, and psychiatric disorders due to METH abuse. In addition, differential expression (DE) ncRNAs also suggest that specific responses and sensitivity to METH neurotoxicity exist in different brain regions and cells. We summarized the relationships between the ncRNAs and METH-induced neurotoxicity and psychiatric disturbances, respectively, hoping to provide new perspectives and strategies for the prevention and treatment of METH abuse.

• 单位
  南方医科大学