Research progress on the role of the Wnt signaling pathway in pituitary adenoma

作者:Wang, Wencai; Ma, Luyao; Zhao, Yongqiang; Liu, Menghao; Ye, Wei; Li, Xianfeng*
来源:Frontiers in Endocrinology, 2023, 14: 1216817.
DOI:10.3389/fendo.2023.1216817

摘要

Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.

  • 单位
    哈尔滨医科大学

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