Electrochemical Oxidative C(sp3)-H Sulfonylation of Xanthenes with Sodium Sulfinates

作者：Wei Bin; Zhou Zilong; Qin Jinghao^*; Yan Zeyu; Guo Jiacheng; Lei Shu; Xie Yexiang; Ouyang Xuanhui^*; Song Renjie^*

来源：CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 43(1): 186-194.

DOI：10.6023/cjoc202207012

• electrooxidation
• sulfonylation
• xanthene
• sodium sulfinate

A direct electrochemical sulfonylation of C(sp(3))-H bonds of xanthenes with sodium sulfinates was studied. A wide variety of 9-(arylsulfonyl)-9H-xanthenes and 9-(alkylsulfonyl)-9H-xanthenes were constructed in a single step at room temperature. This reaction proceeded through a radical pathway and a new C-S bond was formed under this electrochemical sulfonylation transformation. The significant advantages of this strategy include transition metal- and additional oxidant-free, mild reaction conditions, operational simplicity, broad substrate scope and excellent functional group tolerance.

• 单位
  南昌航空大学