Inhalable GSH-Triggered Nanoparticles to Treat Commensal Bacterial Infection in In Situ Lung Tumors

作者：Ma, Zunwei; Wang, Huaiming; Shi, Zhifeng; Yan, Fengying; Li, Qingtao; Chen, Junjian^*; Cui, Zhong-Kai; Zhang, Yunjiao; Jin, Xin; Jia, Yong-Guang^*; Wang, Lin^*

来源：ACS Nano, 2023, 17(6): 5740-5756.

DOI：10.1021/acsnano.2c12165

• lung cancer
• nebulized inhalation
• commensal bacteria
• antimicrobial peptide
• click chemistry

Bacterial infection has been considered one of the primary reasons for low survival rate of lung cancer patients. Herein, we demonstrated that a kind of mesoporous silica nanoparticles loaded with anticancer drug doxorubicin (DOX) and antimicrobial peptide HHC36 (AMP) (MSN@DOX-AMP) can kill both commensal bacteria and tumor cells under GSH-triggering, modulating the immunosuppressive tumor microenvironment, significantly treating commensal bacterial infection, and eliminating in situ lung tumors in a commensal model. Meanwhile, MSN@DOX-AMP encapsulated DOX and AMP highly efficiently via a combined strategy of physical adsorption and click chemistry and exhibited excellent hemocompatibility and biocompatibility. Importantly, MSN@DOX-AMP could be inhaled and accumulate in lung by a needle-free nebulization, achieving a better therapeutic effect. This system is expected to serve as a straightforward platform to treat commensal bacterial infections in tumors and promote the translation of such inhaled GSH-triggered MSN@DOX-AMP to clinical treatments of lung cancer.

• 单位
  南方医科大学; 6; 中山大学