Association between olfactory function and quality of life in patients with olfactory disorders: a multicenter study in over 760 participants

作者：Zou, Lai-Quan; Hummel, Thomas; Otte, Martin S.; Bitter, Thomas; Besser, Gerold; Mueller, Christian A.; Welge-Luessen, Antje; Bulut, Olcay Cem; Goektas, Oender; Negoias, Simona; Li, Shu-bin; Haehner, Antje^*

来源：RHINOLOGY, 2021, 59(2): 164-172.

DOI：10.4193/Rhin20.403

• anosmia
• hyposmia
• olfactory disorder
• parosmia
• quality of life
• smell loss

Background: This cross-sectional, multi-centric study aimed to investigate the differences in quality of life among patients with olfactory dysOD) of different origin, and to identify factors associated with olfactory-related quality of life (QOL). @@@ Methods: Seven hundred sixty-three adults were recruited from 8 Smell & Taste clinics in Germany, Switzerland, and Austria. Olfactory-related QOL was assessed by the Questionnaire of Olfactory Disorders (QOD). Olfactory function was assessed with the "Sniffin' Sticks" test; self-assessment was performed with visual analog scales. @@@ Results: Patients with post-infectious and post-traumatic OD showed poorer olfactory-related QOL than patients with sinonasal and idiopathic OD. The olfactory-related QOL was positively associated with the Sniffin' Sticks test score, self-assessed olfactory function, disease duration, and age, with younger olfactory dysfunction patients showing lower QOL. Female patients presented with poorer olfactory-related QOL. In addition, the results showed that self-assessment of olfactory function explained more of the variance in olfactory-related QOL than olfactory function evaluated by the Sniffin' Sticks test. @@@ Conclusions: In addition to the psychophysical testing results, several factors such as disease cause, disease duration, sex, or self-assessed olfactory dysfunction should be taken into account when assessing the individual severity of the smell loss.

• 单位
  南方医科大学