808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy

作者：Liu, Ze-Yu; Tang, Xiao-Yue; Huang, Chuan-Qing; Zhang, Jin; Huang, Wen-Qian; Ye, Yong^*

来源：Inorganic Chemistry Frontiers, 2022, 9(8): 1836-1846.

DOI：10.1039/d1qi01569a

• RESISTANT-BACTERIA
• DEFATTED SEEDS
• PHOTOSENSITIZER
• DRUG
• LUMINESCENCE
• SAPOGENIN
• OLEIFERA
• EFFICACY
• SAPONIN

Antibacterial upconversion nanoparticles (UCNP)-based photodynamic-chemical combined therapy (UCNP-aPCCT) provides an ideal method to solve the problem of antibiotic-resistant bacteria in deep-tissue infections. Saponin is a kind of natural product exhibiting promising antibacterial activity. Curcumin is also a natural product that could be used as photosensitizer for antibacterial photodynamic therapy (aPDT). Herein, we have designed the dual-layer silica-coated upconversion nanoparticles combined with UCNP-photodynamic therapy (PDT) and chemotherapy using curcumin as a photosensitizer and the Camellia sapogenin derivative (CSD) as an antibacterial agent. It turned out that the prepared UCNP@mSiO(2)(Cur)@DmSiO(2)(CSD)@PVP nanoparticles displayed high antibacterial activity against Escherichia coli and Staphylococcus aureus under near-infrared (NIR) irradiation at 808 nm. Its antibacterial activity is stronger than that of the simple sum of saponin and curcumin aPDT, indicating the existence of a synergetic photodynamic-chemical effect. The current nanoparticle drug system may have potential applications for deep-tissue anti-infection treatment.

• 单位
  y; 广东省农业科学院