科研之友
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摘要
An efficient Cu-catalyzed Ullmann-type C-O coupling of o- haloanilides was developed. This method permits regioselective 2-ethoxylation of N-(2-bromoaryl)-or N-(2-iodoaryl)picolinamides in eth-anol with Cu(OAc)(2) as a convenient catalyst and with picolinamide as a directing group and intramolecular ligand. The reaction is characterized by good regioselectivity, high yields, and the absence of the need for an additional ligand.
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单位云南大学
