New sesquiterpene from a soil fungus of Trichoderma sp

作者：Huang, Ruifeng; Zhou, Runhong; Zhou, Shaofen; Lin, Haixing; Lu, Shengsheng; Qiu, Jingnan; He, Jian^*

来源：NATURAL PRODUCT RESEARCH, 2022.

DOI：10.1080/14786419.2022.2159398

• Antiviral activity
• sesquiterpenoids
• soil fungus
• Trichoderma sp

Sixteen secondary metabolites, including one new sesquiterpene (1, named isocyclonerodiol oxide), seven known sesquiterpenes (2-8), two sorbicillinoid polyketides (15, 16), and six known other compounds (9-14) were isolated from the fermentation broth of Trichoderma sp. T-4-1. The structure of 1 was determined by 1 D, 2 D NMR (HMBC, HSQC, H-1-H-1 COSY, NOESY), and HRESIMS spectra. In addition, sesquiterpenes and sorbicillinoid polyketides showed significant antiviral activities.

• 单位
  南方医科大学