Association between ADAMTS14_rs4747096 gene polymorphism and bone mineral density of Chinese Han population residing in fluorine exposed areas in ShanXi Province, China

作者：Qin, Ming; Gao, Yue; Zhang, Meichen; Wu, Junhua; Liu, Yang; Jiang, Yuting; Zhang, Xiaodi; Wang, Xin; Yang, Yanmei; Gao, Yanhui^*

来源：Environmental Science and Pollution Research, 2023, 30(48): 106059-106067.

DOI：10.1007/s11356-023-29698-w

• Bone mineral density
• ADAMTS14_rs4747096
• Fluoride
• Osteopenia
• Osteoporosis

This study aimed to investigate the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The survey was explored in a cross-sectional case-control study conducted in Shanxi, China. The BMD was measured by an ultrasonic bone mineral density instrument. The urine fluoride concentration was detected using the fluoride ion electrode. ADAMTS14_rs4747096 polymorphism was examined by multiplex polymerase chain reaction (PCR) and sequencing. The multinomial logistic regressions found that the urine fluoride was a risk factor for osteopenia (OR=1.379, 95% CI: 1.127-1.687, P=0.0018), osteoporosis (OR=1.480, 95% CI: 1.1138-1.926, P=0.0035), and rs4747096 AG+GG genotype increased the risk of osteoporosis (OR=2.017, 95% CI: 1.208-3.369, P=0.0073). In addition, the interaction between urine fluoride and rs4747096 polymorphism on the risk of decreased BMD also was observed. The study suggests that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for the decrease of BMD. And there is an interaction between the two influencing factors.

• 单位
  哈尔滨医科大学