Association of visceral adiposity index with new-onset type 2 diabetes and impaired fasting glucose in hypertensive Chinese adults

作者：Zhou, Chun; Zhang, Zhuxian; Liu, Mengyi; Zhang, Yuanyuan; He, Panpan; Li, Qinqin; Xie, Di; Liang, Min; Wang, Guobao; Nie, Jing; Liu, Chengzhang; Song, Yun; Liu, Lishun; Wang, Binyan; Wang, Xiaobin; Xu, Xiping; Qin, Xianhui^*

来源：Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity, 2022, 27(2): 505-514.

DOI：10.1007/s40519-021-01187-4

• Visceral adiposity index
• New-onset type 2 diabetes
• New-onset impair fasting glucose
• Hypertension

Purpose Visceral adiposity index (VAI) is a reliable indicator for the distribution and function of adipose tissue in the body. The relation of VAI with new-onset type 2 diabetes and new-onset impaired fasting glucose (IFG) remains uncertain. We aimed to investigate the prospective relation of VAI with new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive adults. Methods A total of 14,838 hypertensive adults free of type 2 diabetes at baseline were included from the China Stroke Primary Prevention Trial. The primary outcome was new-onset type 2 diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose >= 7.0 mmol/L at the exit visit. The secondary outcome was new-onset IFG, defined as fasting glucose < 6.1 mmol/L at baseline, while fasting glucose >= 6.1 mmol/L and < 7.0 mmol/L at the exit visit. Results Over a median of 4.5 years' follow-up, 1612 (10.9%) participants developed type 2 diabetes. When VAI was categorized into quartiles, compared with participants in quartile 1-3 (< 2.80), significantly higher risk of new-onset type 2 diabetes (OR 1.30; 95% CI 1.08-1.56) and new-onset IFG (OR 1.28; 95% CI 1.08-1.52) was found in those in quartile 4 (>= 2.80). Moreover, the positive associations were consistent in participants with or without single abnormal VAI components, including general obesity, abdominal obesity, elevated triglycerides and low high-density lipoprotein cholesterol (HDL-C) levels; or with different numbers of abnormal VAI components (all P interactions > 0.05). Conclusion Our study suggested a positive relation of VAI with the risk of new-onset type 2 diabetes and new-onset IFG in Chinese hypertensive patients, independent of its components.

• 单位
  中国农业大学; 南方医科大学; 安徽医科大学