An In silico Predictive Analysis of Mepivacaine-GABA Interaction

摘要

Gamma-aminobutyric acid (GABA) is an amino acid that is non-proteinogenic in nature, which functions as a predominant neurotransmitter in the central nervous system (CNS) of the human body. Mepivacaine, first introduced in the 1960s, is used as a vasodilator majorly in the fields of dentistry. If the primary functions of both agents may be inhibited by the action of other compounds working in the same manner, it may induce toxicity or stress in the cells. The advertent or inadvertent use of phytochemicals with local anesthetics can result in either synergistic or antagonistic effects in the human body, which is ultimately dependent upon various factors. This elucidation of this type of interaction and the subsequent effects it entailed in the human body, was the main focus of the predictive study. The possible effects of combined administration of Mepivacaine and GABA was investigated by ChemDIS-Mixture (v.5.0, medium confidence score 0.4). The significance level for the analysis was set at 0.05, with Benjamini-Hochberg multiple test correction. The findings of the study elucidated various proteins, signalling pathway, GO, DO, and DOLite terms that are shared between Mepivacaine and GABA when they are taken simultaneously. This study revealed 08 new GO term, 04 signaling pathways, 17 DO terms and 21 DOLite terms associated with their interaction. Personalized treatment with a deeper understanding of known herbal and conventional drugs is the major requirement of the study, which could superlatively prevent any type of antagonistic effects that could take place.

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