In Situ Construction of Black Titanium Oxide with a Multilevel Structure on a Titanium Alloy for Photothermal Antibacterial Therapy

作者：Yang, Fabang; Zhang, Zhekun; Li, Yuanxing; Xiao, Cairong; Zhang, Huan; Li, Wei; Zhan, Lizhen; Liang, Guoyan; Chang, Yunbing; Ning, Chengyun; Zhai, Jinxia^*; Zhou, Zhengnan^*; Yu, Peng^*

来源：ACS Biomaterials Science & Engineering, 2022, 8(6): 2419-2427.

DOI：10.1021/acsbiomaterials.2c00256

• orthopedic postsurgical infection
• multilevel structure
• lattice defects
• photothermal antibacterial
• titanium implant

Postsurgical infection of orthopedic fixation materials is considered to be the main cause of fixation failure. To address the problem, clinical treatment often relies on long-term antibiotics, secondary surgery, and so forth, which cause pain and suffering to patients. Constructing a light-responsive surface structure on the implant has attracted widespread attention for the management of postsurgical infections because of its noninvasiveness and controllability. Nevertheless, the application of light-responsive structures on implants is still limited by their unsafety and instability. In this work, a black titanium oxide layer with a multilevel structure and lattice defects was in situ constructed on a titanium alloy through pulsed laser ablation treatment. Under the synergistic effect of the multilevel structure and crystal defects, the surface of the titanium alloy exhibited good near-infrared light-responsive photothermal ability. The black titanium oxide multilevel structure reached high antibacterial efficiencies of about 99.37 and 99.29% against Staphylococcus aureus and Escherichia coli under 10 min near-infrared light irradiation. Furthermore, the black titanium oxide layer possessed similar biocompatibility compared with the titanium alloy. This near-infrared light-responsive photothermal therapy based on the construction of a multilevel structure and introduction of lattice defects provides an effective strategy for clinical postsurgical infections of orthopedic fixation.

• 单位
  广东省人民医院