Integrative analysis of disulfidptosis and immune microenvironment in hepatocellular carcinoma: a putative model and immunotherapeutic strategies

作者：Yang, Ti; Liu, Junhao; Liu, Fang; Lei, Jiashun; Chen, Siliang; Ma, Zengxin; Ke, Peifeng; Yang, Qiaolan; Wen, Jianfan^*; He, Yifeng^*; Duan, Juan^*; Zeng, Xiancheng^*

来源：Frontiers in Immunology, 2024, 14: 1294677.

DOI：10.3389/fimmu.2023.1294677

• HCC
• disulfidptosis
• putative model
• immune microenvironment
• NDRG1

BackgroundHepatocellular carcinoma (HCC) is a malignant tumor with a high rate of recurrence and m metastasis that does not respond well to current therapies and has a very poor prognosis. Disulfidptosis is a novel mode of cell death that has been analyzed as a novel therapeutic target for HCC cells.MethodsThis study integrated bulk ribonucleic acid (RNA) sequencing datasets, spatial transcriptomics (ST), and single-cell RNA sequencing to explore the landscape of disulfidptosis and the immune microenvironment of HCC cells.ResultsWe developed a novel model to predict the prognosis of patients with HCC based on disulfidptosis. The model has good stability, applicability, and prognostic and immune response prediction abilities. N-myc downregulated gene1 (NDRG1) may contribute to poor prognosis by affecting macrophage differentiation, thus allowing HCC cells to evade the immune system.ConclusionOur study explores the disulfidptosis of HCC cells through multi-omics and establishes a new putative model that explores possible targets for HCC treatment.

• 单位
  1; 南方医科大学; 广东省人民医院; 广州中医药大学