Frequency-resolved connectome alterations in major depressive disorder: A multisite resting fMRI study

作者：Wang, Lei; Ma, Qing; Sun, Xiaoyi; Xu, Zhilei; Zhang, Jiaying; Liao, Xuhong; Wang, Xiaoqin; Wei, Dongtao; Chen, Yuan; Liu, Bangshan; Huang, Chu-Chung; Zheng, Yanting; Wu, Yankun; Chen, Taolin; Cheng, Yuqi; Xu, Xiufeng; Gong, Qiyong; Si, Tianmei; Qiu, Shijun; Lin, Ching-Po; Cheng, Jingliang; Tang, Yanqing; Wang, Fei; Qiu, Jiang; Xie, Peng; Li, Lingjiang; He, Yong; Xia, Mingrui; Zhang, Yihe

来源：Journal of Affective Disorders, 2023, 328: 47-57.

DOI：10.1016/j.jad.2023.01.104

• Resting -state functional magnetic resonance
• imaging
• Major depressive disorder
• Functional connectivity strength
• Frequency

Background: Functional connectome studies have revealed widespread connectivity alterations in major depressive disorder (MDD). However, the low frequency bandpass filtering (0.01-0.08 Hz or 0.01-0.1 Hz) in most studies have impeded our understanding on whether and how these alterations are affected by frequency of interest.Methods: Here, we performed frequency-resolved (0.01-0.06 Hz, 0.06-0.16 Hz and 0.16-0.24 Hz) connectome analyses using a large-sample resting-state functional MRI dataset of 1002 MDD patients and 924 healthy controls from seven independent centers.Results: We reported significant frequency-dependent connectome alterations in MDD in left inferior parietal, inferior temporal, precentral, and fusiform cortices and bilateral precuneus. These frequency-dependent con-nectome alterations are mainly derived by abnormalities of medium-and long-distance connections and are brain network-dependent. Moreover, the connectome alteration of left precuneus in high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.Limitations: Multisite harmonization model only removed linear site effects. Neurobiological underpinning of alterations in higher frequency (0.16-0.24 Hz) should be further examined by combining fMRI data with respiration, heartbeat and blood flow recordings in future studies.Conclusions: These results highlight the frequency-dependency of connectome alterations in MDD and the benefit of examining connectome alteration in MDD under a wider frequency band.

• 单位
  广州中医药大学; 中国医科大学; 1; 中国医学科学院; 北京大学; 郑州大学; 四川大学; 西南大学; 复旦大学