Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer

作者：Dai, Jianhua; He, Xiu; Li, Zhuoyue; Li, Kang; Yang, Tingting; Ran, Zengling; Yin, Lijian; Chen, Yao; Zou, Xiang; Fang, Dianchun^*; Peng, Guiyong^*

来源：Photonic Sensors, 2019, 9(1): 53-59.

DOI：10.1007/s13320-018-0516-7

• Fiber-optic
• Raman spectrum
• esophageal cancer

A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination. The system contains a 785 nm exciting laser, a Raman fiber-optic probe with 7 large core fibers and a focus lens, and a highly sensitive spectrum meter. The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality. A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed, based on the differences in half-height width (HHW) in 1200 cm(1) to 1400 cm(1) frequency band and the ratios of the spectral integral energy between 1600 cm(1) - 1700 cm(1) and 1500 cm(1) - 1600 cm(1) band. It shows a high specificity and effectivity for the diagnosis of esophageal cancer.

• 单位
  电子科技大学