Aristolochic alkaloids from Piper macropodum and their anti-inflammatory activities

作者：Liu, Chun-Yue; Lu, Yong-Fu; Liu, Si-Xuan; Li, Yong-Fu; Dong, Yan; Li, Chang^*; Pei, Yue-Hu^*

来源：Phytochemistry Letters, 2023, 57: 163-166.

DOI：10.1016/j.phytol.2023.08.012

• Aristolochic lactam alkaloids
• Piperumberllactam E
• NO releasing

Five aristolochic lactam alkaloids (1-5), including two new ones (1-2), along with two new natural products (6- 7) were isolated from Piper macropodum. The structures of the new compounds (1-2) were elucidated by extensive spectroscopic analysis. The structures of compounds (3-7) were identified on the basis of NMR spectroscopic data analyses and comparison with the data reported in literature. Consequently, compounds 1-5 showed good inhibitory effects on NO releasing from RAW264.7 cells induced by LPS.

• 单位
  哈尔滨医科大学