Rhodium-Catalyzed Direct Vinylene Annulation of Sulfoxonium Ylides and N-carbamoylindoles with Vinylene Carbonate

作者：Song, Jia-Lin; Xiao, Lin; Chen, Shao-Yong; Zheng, Yi-Chuan; Liu, Yan-Zhi; Zhang, Shang-Shi^*; Shu, Bing^*

来源：Advanced Synthesis and Catalysis, 2023, 365(9): 1457-1464.

DOI：10.1002/adsc.202300135

• Vinylene Carbonate
• Rh(III)-Catalyzed
• Sulfoxonium Ylides
• N-carbamoylindoles
• Annulation

In this study, Rh(III)-catalyzed C-H bifunctionalization and direct vinylene annulation of sulfoxonium ylides and N-carbamoylindoles with vinylene carbonate was accomplished, which afforded a series of naphthalenones containing a beta- ketosulfoxonium ylide moiety, isocoumarins, and pyrimidones. This protocol featured mild conditions, broad substrate scope, and functional-groups compatibility. In addition, related applications and preliminary mechanistic exploratory were also investigated

• 单位
  广东药学院